NAD+ and How It Can Help Balance Women’s Hormones

Oct 22

Hormone health is foundational to women’s well-being influencing everything from energy levels and mood to fertility and metabolism. If you’re navigating challenges like fatigue, menstrual irregularities, PCOS, or perimenopausal symptoms, you may be seeking natural ways to support hormonal balance. One emerging tool in the wellness space is NAD+ IV therapy.

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It plays a central role in:

Energy production (especially in mitochondria)
DNA repair
Cellular stress response
Metabolic regulation
Inflammation control

Unfortunately, NAD+ levels decline naturally with age, stress, poor sleep, alcohol use, and chronic illness. This depletion is linked to fatigue, cognitive decline, and, increasingly, hormone dysregulation.

NAD+ and Women’s Hormonal Health

While NAD+ is not a hormone itself, research suggests it may influence hormonal balance through several key mechanisms:

1. Mitochondrial Function for Hormone Production

Ovaries, adrenal glands, and other hormone-producing tissues rely heavily on mitochondrial energy. NAD+ fuels these mitochondria, potentially supporting hormone synthesis and regulation.

2. Reducing Inflammation and Oxidative Stress

Hormonal imbalances often involve chronic inflammation and oxidative stress, especially in conditions like PCOS or premature ovarian aging. NAD+ helps activate sirtuins, a family of enzymes that protect against cellular damage and inflammation. A 2024 review found that NAD+ supplementation helped reduce ovarian inflammation and fibrosis in PCOS mouse models.

3. Insulin Sensitivity and Metabolism

Insulin resistance can drive hormonal imbalances, particularly in PCOS. Several studies have shown that NAD+ precursors improve insulin signaling and metabolic markers in animals, with promising implications for women with hormone-related metabolic issues.

4. Ovarian Aging and Fertility

Perhaps most compelling is NAD⁺'s potential role in female fertility. As women age, ovarian NAD+ levels decline, correlating with poorer egg quality. Animal studies suggest that replenishing NAD+ may rejuvenate egg health and extend reproductive longevity. While more human trials are needed, this preclinical evidence is driving interest in NAD+ as a fertility-supportive and hormone-optimizing therapy.

How NAD+ is Delivered: Why IV Therapy?

At Sierra IV Hydration, we offer NAD+ through IV infusion for maximum absorption and rapid cellular uptake.

Why IV NAD+?

Bypasses digestion for faster, more reliable effects
Higher concentrations than oral supplements
May support energy, mental clarity, and stress resilience within hours

We also offer custom infusion blends, pairing NAD+ with B-vitamins, magnesium, and antioxidants to support hormone health from multiple angles.

Ready to Explore NAD+ Therapy?

If you’re struggling with hormone-related fatigue, irregular cycles, or looking to optimize your fertility and wellness, NAD+ therapy may be worth exploring.

At Sierra IV, we provide: